Signe Wilkinson is one of contemporary America's few women cartoonists. A native Philadelphian, Wilkinson began her career as a journalist for the Daily Local News in suburban West Chester, PA. She soon realized her interest in cartooning as she began drawing the subjects she was supposed to be covering. After attending the Pennsylvania Academy of the Fine Arts and freelancing, Wilkinson joined the staff of the San Jose Mercury News. In 1985 she returned to Philadelphia as a contributing artist at the Philadelphia Daily News.

Wilkinson was the first woman to win the Pulitzer Prize for editorial cartooning in 1992 and served as the president of the Association of American Editorial Cartoonists in 1994–1995. She contributes cartoons regularly to Organic Gardening magazine, the Institute for Research on Higher Education, and Oxygen.com.

In cartoons from 1991 to the present, Wilkinson deftly wields her pen at local, national, and international politics. Though she examines a wide array of subjects, Wilkinson is best known for her insightful cartoons focusing on family and women's issues.